A man with hemophilia (a recessive , sex-linked condition has a daughter of normal phenotype. She marries a man who is normal for the trait. What is the probability that a daughter of this mating will be a hemophiliac? A son? If the couple has four sons, what is the probability that all four will be born with hemophilia?
A man with hemophilia is XhY where h = hemophilia gene and H = the normal gene.
Any daughter with normal phenotype whose father has hemophilia will be a carrier.
Her genotype must be:
XhXH and NOT XHXH
We can use a Punnett square to show the probability of a daughter or son having hemophilia.
daughter x normal man
XhXH x XHY
A. If the daughter marries a normal male the probability of a daughter having hemophilia is zero.
B. About 50%of male children would have hemophilia (Boxes 2 and 4 above)
C. The probability that all 4 sons have inherited hemophilia would be: 1/2 x 1/2 x 1/2 x 1/2 or 1/16.
You have been challenged to incorporate your knowledge about cells, cell division, genetics, and DNA to research and present on a specific genetic disorder. You have already completed your basic study about the ideas of genetics and mutations. Now with the information that you have you are being asked to research a specific genetic disorder and give an oral presentation along with creating either a PowerPoint or poster to explain the genetic disorder.
Your multimedia presentation (powerpoint / poster) along with your oral presentation
should include the following points.
What is the name of the disorder and what is the history behind the disorder? Who discovered it or/and who have done research on the disease?
How is the disorder diagnosed? How does a person receive the disorder? Is it sex-linked? Is it a mutation? Is it due to heredity?
You will need to find out all of the signs and symptoms of the given disorder and share these with the class.
What types of treatment there are for the disorder?
Include a suggested list of readings and/or Internet sources that may be of interest to the class.
You are encouraged to share any other information that you feel is relevant that you feel is important for others to know about the genetic disorder.
List of possible Genetic Disorders to Present:
Autism/ Asperger syndrome
Down Syndrome (Trisomy 21)
Duchenne Muscular Dystrophy
Gardner syndrome (intestinal polyposis)
Lou Gehrig’s Disease (ALS)
Polycystic Kidney Disease
List of internet resources that may be helpful to you in creating your presentation:
Yahoo – Genetic Disorders http://dir.yahoo.com/Health/Diseases_and_Conditions/Genetic_Disorders/.
Site explains several different disorders and contains links to all of the different types of genetic disorders.
All labs must be written in pencil and be submitted to the teacher in a spiral notebook.
Always use third person (NO personal pronouns — me, I, you, we, etc.) when writing all parts of a lab report. (USE HE, SHE, THEY, THEIR, THEM, ETC.
The following things should be written clearly in marker on the front cover — “Subject” Lab Notebook, teacher name, student name, period.
Number each page of the spiral notebook in the lower right hand corner.
On Page 1, write the subject, year, student name, class period, and teacher name.
Page 2 should have “Table of Contents” written at the top and two columns, one for “Page” and the other for “Lab Title”.
Begin writing the first lab on page 3 of you notebook. DO NOT WRITE ON THE BACK OF YOUR PAPER!
SKIP A LINE BETWEEN EVERY SECTION!
TITLE and UNDERLINE each section & then begin writing on the NEXT LINE!
Your lab report should be written using the following format: (Be sure to left align & underline headings)
Title (center on top line; on the right of line 2, put date & lab #) The title should indicate clearly & concisely the subject and scope of the report.
Introduction – 20 points (PARAGRAPH FORM)
The introduction should give background information about the experiment.
It should also state the purpose of the investigation.
This section will be two or more paragraphs in length.
Hypothesis – 20 points (SINGLE SENTENCE)
The hypothesis should be a single statement telling the exact thing you are trying to prove in your experiment.
NEVER write this statement using “first person”. Write the hypothesis in past tense (third person.)
Materials – 5 points (SINGLE SENTENCE)
This section should be written in sentence form and name all of the materials and equipment used.
Be sure to include specific amounts and concentrations of chemicals used.
Start the statement, “The materials used include _____, _____, etc.”
Methods (Procedure)- 5 points (STEPS; NUMBER)
This section includes the step-by-step procedures used.
The procedure should be so thorough that someone else could use your listed materials and procedures to conduct the same experiment and get the same results.
Results (Data & Questions) – 20 points
All data should be collected and organized in a logical order. Results should be illustrated as charts, tables, graphs, &/or diagrams. All graphs should include a title, the independent variable labeled on the horizontal axis, and the dependent variable labeled on the vertical axis.
All lab questions and answers should be included also with this section. ( NUMBER & UNDERLINE the questions & then write, but DON’T UNDERLINE the answers)
SKIP ONE LINE BETWEEN EACH QUESTION!
Include any important factors that you think may have actually affected your results.
Discussion and Conclusion – 30 points
Discussion is the most important part of your report, because here, you show that you understand the experiment beyond the simple level of completing it.!!
Your conclusion MUST CONTAIN YOUR SUPPORTING DATA!
This is where you give a detailed account of what happened in the experiment.
Explain all observations and results in your experiment.
Analyze and interpret why these results were obtained.
Be sure to tell the significance or meaning of the results.
Restate the original hypothesis and explain whether the experiment succeeded. If the hypothesis was not correct, you should analyze why the results were not as predicted.
Explain experimental errors that appear in the results.
QUESTIONS MUST BE ANSWERED & CONCLUSION WRITTEN TO RECEIVE LAB CREDIT!