ap lectureguide12

AP Biology: CHAPTER 12

 CELL CYCLE

1. What is meant by the concept that cells go through a cell cycle?

__________________________________________________________________________

__________________________________________________________________________

2. What are the key roles of cell division?

__________________________________________________________________________

__________________________________________________________________________

3. What is the significance of chromosome replication?

__________________________________________________________________________

__________________________________________________________________________

4. Sketch and label replicated chromosomes.

 

 

5. List the phases of the cell cycle with a brief description of what occurs in each phase.

a. _______________________________________________________________________

b. _______________________________________________________________________

c. _______________________________________________________________________

d. _______________________________________________________________________

e. _______________________________________________________________________

6. Label the stages and key features of each stage.

7. How does the spindle apparatus distribute chromosomes to the daughter cells?

__________________________________________________________________________

__________________________________________________________________________

8. What is the role of the kinetochores and the microtubules?

__________________________________________________________________________

__________________________________________________________________________

9. How does cytokinesis differ in animal and plant cells? Label the diagrams below.

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________

10. Eukatyotic mitosis is thought to have evolved from _________________________________

11. Why is the regulation of the cell cycle critical to normal cells?

__________________________________________________________________________

__________________________________________________________________________

12. What is the G1 checkpoint and where does it fit into the cycle?

__________________________________________________________________________

__________________________________________________________________________

13. What evidence is there that regulation is chemical in nature?

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________

14. Identify the role of the following in the cell cycle clock:

a. Kinase _________________________________________________________________

__________________________________________________________________________

b. Cyclin _________________________________________________________________

__________________________________________________________________________

c. CDKs _________________________________________________________________

__________________________________________________________________________

15. Describe the mechanism for regulating the passage of the cell into anaphase.

__________________________________________________________________________

__________________________________________________________________________

16. Describe what triggers mitosis from G2.

__________________________________________________________________________

__________________________________________________________________________

17. What is the role of ubiquitin?

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________

18. Describe a model for an external signal for growth.

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________

19. What happens when cancer develops?

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________

20. What is the role of p53?

__________________________________________________________________________

__________________________________________________________________________

__________________________________________________________________________